The convergence of these two fields—genomics, marked by the rapidly plummeting cost of sequencing a person’s entire genetic code, and wireless, with its flurry of innovative health-care apps—led Dr. Topol to write “The Creative Destruction of Medicine,” a book that offers an illuminating perspective on the coming digitization of health care. It’s also a reminder that while medicine is one of the globe’s premier drivers of innovation, it is also a conservative culture that now finds itself buffeted by transformational change.